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Author Topic: PKD/DNA test kits  (Read 4376 times)
lync

Posts: 1314


« on: December 27, 2007, 06:58:34 AM »

I recently lost my cat to kidney failure and after reading up on this I find that Persians carry this gene more often than other breeds.  There is a kit you can do at home on your cats with a cotton swab and mail back to the lab for testing for this gene.  It costs $40.  Here is the link:

http://www.vgl.ucdavis.edu/

I am sort of obsessed now with this PKD worry and would only buy a cat that has come from a cattery that has PKD negative parents.  I would want this test done on any kitten.  I even have been considering testing my 12 year old Himmie to see if he carries the gene because he is 1/2 brother to Casey.  Casey died 12/3/07.  I wonder how many breeders are doing this?  I read that 37% of the Persians out there -- includes Himmies  -- carry this gene.  That it has gone on for years and not too much attention has been brought to this subject.  Any opinions?
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Bobby and Bonnie
Whispurrpaws

Posts: 2150


« Reply #1 on: December 27, 2007, 08:44:31 AM »

I believe ANY breeder that hasn't already tested, isn't in the process of testing, or is simply unwilling to DNA test their cats for PKD SHOULD NOT be breeding in the first place.  They are doing absolutely NOTHING to help eliminate this disease from the Persian breed and only perpetuating the PKD problem.  There is absolutely NO reason why EVERY Himmie, Persian & Exotic breeder shouldn't be DNA testing their cats for this disease.

I personally started testing my Himmies & Persians for PKD when the DNA test first became available back in 2005.  I am very proud to say that ALL cats currently in my breeding program are DNA PKD Negative.  Breeders and pet buyers alike need to get educated about PKD and should only buy cats/kittens from DNA PKD negative tested parents.  If the breeder cannot supply you proof that both parents have been DNA tested and are negative, insist the cat or kitten be tested themselves before purchase.  $40 is a very small price to pay to ensure you are getting a cat or kitten that is DNA PKD negative.

Just my personal opinion, of course.

Tracy J. Hopkins
Whispurrpaws Himalayans & Persians
A DNA PKD Negative Tested Cattery
http://www.whispurrpawscattery.info/
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Tracy J. Hopkins
Whispurrpaws Persians & Himalayans
Beauty, Health & Purrsonality Plus!!
A DNA PKD Negative Tested Cattery
http://www.whispurrpawscattery.info/
lync

Posts: 1314


« Reply #2 on: December 27, 2007, 11:12:03 AM »

Here Here Tracy!!  Cheers to you!  I wish I saw more of this from breeders' webpages.  More awareness.
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Bobby and Bonnie
Bluepoem

Posts: 843


« Reply #3 on: December 28, 2007, 01:02:11 AM »

I agree with Tracy. This test is obligatory for any responsible breeder ...but is almost useless for other, because don't help with anything the sick cat or the owner. Sad
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Lauradam Persians

Posts: 185


« Reply #4 on: December 28, 2007, 01:44:42 AM »

Yes testing is very important, all of my breeding cats are tested and are pkd negative, we must put a stop to pkd. Unfortunetaly there are breeders who are more bothered about making money than selling healthy kittens.

Lynn
Lauradam Persians
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vrgchs

Posts: 737


« Reply #5 on: December 30, 2007, 01:08:49 AM »

I totally agree with you Tracy.  If you are not going to test, then you shouldn't be breeding.  It is a sad disease and breeders should do all they can to eliminate it.
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VALERIE

PURRISTIC Persians & Himalayans
CFA Registered Cattery
http://www.purristic.com
Mari

Posts: 517


« Reply #6 on: December 30, 2007, 01:15:07 AM »

Tracy, you are so right!  How about the people that sell Persians and say all Persians have ringworm :?:  That rubbs me up the wrong way :!: WHATTTTTTTTT :?:

Mari.
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My life is a joy because of my Beautifull Persians!
Whispurrpaws

Posts: 2150


« Reply #7 on: December 31, 2007, 06:42:39 AM »

I'm so glad to see there are others that feel as strongly as I do about eliminating PKD from the Persian breed. Cheesy   I just wish ALL breeders cared as much as we do. :x  

Mari, anyone that tells you that ALL Persians have ringworm doesn't know what they are talking about.:roll:  That statement definitely rubs me the wrong way too!!  While it's true some Persians are prone to ringworm, it certainly doesn't mean the entire Persian population has it.

Happy New Year to all!!:cat:

Tracy J. Hopkins
Whispurrpaws Himalayans & Persians
Beauty, Health & Purrsonality Plus!!
A DNA PKD Negative Tested Cattery
http://www.whispurrpawscattery.info/
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Tracy J. Hopkins
Whispurrpaws Persians & Himalayans
Beauty, Health & Purrsonality Plus!!
A DNA PKD Negative Tested Cattery
http://www.whispurrpawscattery.info/
kissakatje

Posts: 4238


« Reply #8 on: January 11, 2008, 08:49:02 AM »

Quote from: "lync"
I recently lost my cat to kidney failure and after reading up on this I find that Persians carry this gene more often than other breeds.  There is a kit you can do at home on your cats with a cotton swab and mail back to the lab for testing for this gene.  It costs $40.  Here is the link:

http://www.vgl.ucdavis.edu/

I am sort of obsessed now with this PKD worry and would only buy a cat that has come from a cattery that has PKD negative parents.  I would want this test done on any kitten.  I even have been considering testing my 12 year old Himmie to see if he carries the gene because he is 1/2 brother to Casey.  Casey died 12/3/07.  I wonder how many breeders are doing this?  I read that 37% of the Persians out there -- includes Himmies  -- carry this gene.  That it has gone on for years and not too much attention has been brought to this subject.  Any opinions?


So sorry about the loss of your precious kitty.  Kidney disease is a rotten thing.  My vet and breeder both have said that the incidence of PKD in Persians (Persian, Exotics, Himmies) is very high.  It is true that genetic tests (DNA) can be done to test for the gene.  I know there is a blood test for it ... and possibly also a saliva test.  And PKD clear certification can be obtained for cats who do not carry to PKD gene.   Supposedly, if neither parent carried the gene, PKD cannot develop in kittens (but, of course, other sorts of kidney disease still might develop).  Anyhow, the number of breeders testing for it is increasing.  It is no longer an unknown subject and attention is beginning to be paid to it (thank goodness). It's critical that DNA testing of Persian-type cats be done as it's a genuine issue in these cats.

Sorry once again for your painful loss.

Kidney disease of various sorts is also quite prevalent in certain breeds of dog ... like the Shih Tzu (of which I am very fond and have had 2).  It is positively heartbreaking when a beloved pet develops diseases such as these.

Take care
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Katlyn and Tosca

"Tosca ... light of my life"
arobed

Posts: 163


« Reply #9 on: January 11, 2008, 09:24:51 AM »

I think testing for PKD by DNA is absolutely necessary in any responsible breeding program...what I don't understand is why some breeders are unwilling to do it...the test is so easy to do and you do it in your own home, it is relatively inexpensive and Uc  Davis is quick in processinfg the samples.  Here in Quebec more and more breeders are testing for PKD but still so many are having their cats tested by ultrasound (which is not 100% accurate and double the price).  I wonder if it is the language barrier?  Whenever I am talking to breeders I always mention the UC Davis service help to spread the word.  
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Libellula Persians
Quality of Look & Character

http://www.libellulapersians.com
Bluepoem

Posts: 843


« Reply #10 on: January 11, 2008, 11:14:21 AM »

From my unhappy experience:
A few years ago I bought a beautiful cat. The parents - PKD free conformable to the ultrasound's results. Thought, to can be very sure Cool  I had made it another 2 ultrasound tests at 7,5 MHz: at one year old and after 6 months  again - her kidney was clean.
Two years ago I had tested genetic all my producers and the shock was big: this girl was finded positive!
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celeste912

Posts: 1118


« Reply #11 on: January 11, 2008, 01:03:32 PM »

It is only PKD1 that can be diagnosed via DNA.  There is no test to-date that is available for PKD2.  No breeder can guarantee a cat to be PKD2 negative.

Just thought you would like to know. Smiley
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Bluepoem

Posts: 843


« Reply #12 on: January 12, 2008, 12:55:08 AM »

What is PKD1 and PKD2 ? PKD1 negative or PKD2 negative is not the same guarantee for negative kittens? :roll:
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celeste912

Posts: 1118


« Reply #13 on: January 12, 2008, 06:30:21 AM »

My son has been diagnosed with cysts on his kidneys.  Both his grandparents had medical kidney issues, however, did not have cysts on their kidneys. Previous family kidney problems can create this situation also. Medical research is still on going.

Here is a portion of an article which addresses it and I hope it helps:


Yet another explanation for a positive offspring from two negative parents would be a second form of PKD in cats -- Autosomal Recessive PKD.  Autosomal Recessive PKD does exist in humans, but is a childhood onset disease that is almost always fatal before the individual reaches adulthood.  It is theorized that if Autosomal Recessive PKD exists in cats, it would work the same as in humans -- i.e., few if any affected cats would live to adulthood.  While to date, this is just a theory, Dr. DiBartola, professor of Veterinary Clinical Sciences at The Ohio State University notes:

"PKD in very young kittens resembling RECESSIVE PKD has been reported in the veterinary literature.  See Crowell WA, Hubbell JJ and Riley JC. Polycystic renal disease in related cats. J Am Vet Med Assoc 175: 286-288, 1979.  While there is no genetic proof that this manuscript describes ARPKD, it is likely.  The cats in this paper died at around 6 weeks of age as I recall and had SEVERE renal cystic disease.
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Bluepoem

Posts: 843


« Reply #14 on: January 12, 2008, 08:00:33 AM »

Thank you, celeste912! I will ask to a friend to translate me every word, to can be sure I understand correct the text. :?
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